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UID:DSC-18801
DTSTART;TZID=Europe/Berlin:20220421T100000
SEQUENCE:1649714834
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URL:https://dresden-science-calendar.org/calendar/de/detail/18801
LOCATION:IFW\, Helmholtzstraße 2001069 Dresden
SUMMARY:Robles: Microrobotic transport of zygotes and gametes towards in vi
 vo assisted fertilization
CLASS:PUBLIC
DESCRIPTION:Speaker: David Castellanos Robles\nInstitute of Speaker: IFW Dr
 esden\nTopics:\n\n Location:\n  Name: IFW (A1E.10\, Hörsaal\, IFW Dresden
 )\n  Street: Helmholtzstraße 20\n  City: 01069 Dresden\n  Phone: \n  Fax:
  \nDescription: Micromotors have great potential in biomedical application
 s as they can be used for drug delivery\, cell transport\, and microsurger
 y\, among others. In the area of assisted reproduction\, micromotors that 
 transport zygotes and gametes within the female reproductive system will a
 llow less harsh procedures\, reducing the risk of ectopic and multiple pre
 gnancies\, and increasing pregnancy rates. However\, this will require a l
 ot of improvements of the current state of this technology. The main chall
 enges are to improve microrobots’ biocompatibility\, biodegradability\, m
 otion control\, real-time bio-imaging\, stimuli responsivity\, payload tra
 nsport\, and target specificity. In this work\, two ideas to address these
  challenges are presented. The first consists of soft hydrogel-based micro
 robots fabricated by droplet microfluidics with varying sizes (from 20 to 
 120 µm). This technique allows the embedding of materials within the micr
 omotors\, such as contrast agents or drugs. The micromotors are externally
  actuated by rotating magnetic fields and driven with feedback-loop contro
 l. It is shown that the contrast agents loaded into the micromotors enable
  their visualization by ultrasound and photoacoustics in a hybrid fashion.
  It is also demonstrated how these micromotors can biodegrade and deliver 
 drugs in a controlled manner. Second\, an idea to develop a new type of mi
 cromotor with a design that will allow for more efficient movement and inc
 reased functionality is presented. This micromotor can transform and adapt
  its shape to trap and release large payloads. It continues with the previ
 ously developed solutions\, being built with biocompatible and biodegradab
 le materials\, capable of transporting drugs and contrast agents that allo
 w real-time tracking\, and cell cargo-delivery\, towards their in vivo app
 lication.
DTSTAMP:20260707T045338Z
CREATED:20220411T220714Z
LAST-MODIFIED:20220411T220714Z
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