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UID:DSC-19994
DTSTART;VALUE=DATE:20230928
SEQUENCE:1688636505
TRANSP:OPAQUE
DTEND;VALUE=DATE:20231001
URL:https://dresden-science-calendar.org/calendar/de/detail/19994
LOCATION:TUD CRTD\, Fetscherstraße 10501307 Dresden
SUMMARY:EMBO Workshop: Epigenetics and Condensates in Lineage Decisions
CLASS:PUBLIC
DESCRIPTION:Speaker: \nInstitute of Speaker: \nTopics:\nWeiterbildung\nTime
 :\n11:00-18:00\n\n Location:\n  Name: TUD CRTD ()\n  Street: Fetscherstra
 ße 105\n  City: 01307 Dresden\n  Phone: +49 (0)351 458 82052\n  Fax: +49 
 (0)351 458 82059 \nDescription: In metazoan development\, epigenetic mecha
 nisms are required for the transition from multipotency to lineage commitm
 ent. Epigenetic regulation contributes to the extraordinary reproducibilit
 y and stability of multiple lineage decisions during gastrulation and orga
 nogenesis. Recent evidence indicates that phase transitions in the nucleus
  are involved in epigenetic mechanisms including the regulation of gene ex
 pression and therefore\, potentially\, lineage decisions. The perception o
 f nuclear proteins as structured folds with extra disordered regions that 
 can be ignored has fundamentally shifted. Intrinsically disordered regions
  (IDRs)\, often together with nucleic acids\, are now thought to assemble 
 into condensates in the nucleus. Several nuclear condensates have been doc
 umented\, including the nucleolus\, and recently\, heterochromatin. Eviden
 ce that condensates are involved in the regulation of gene expression is a
 lso emerging. This EMBO Workshop is based on the anticipation that condens
 ates in the nucleus will be involved in the regulation of gene expression 
 through epigenetic mechanisms. Conversely\, epigenetic mechanisms likely i
 nclude phase transitions to regulate gene expression. This EMBO Wworkshop 
 aims to juxtapose the frontier of condensates and phase transitions with c
 hromatin and the epigenetics of early developmental transcriptional decisi
 ons in higher metazoans. We aim to catalyze interdisciplinary discussion a
 nd speculations at the forefront of an emerging interface.  
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DTSTAMP:20260422T002558Z
CREATED:20230706T065608Z
LAST-MODIFIED:20230706T094145Z
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