BEGIN:VCALENDAR
VERSION:2.0
PRODID:www.dresden-science-calendar.de
METHOD:PUBLISH
CALSCALE:GREGORIAN
X-MICROSOFT-CALSCALE:GREGORIAN
X-WR-TIMEZONE:Europe/Berlin
BEGIN:VTIMEZONE
TZID:Europe/Berlin
X-LIC-LOCATION:Europe/Berlin
BEGIN:DAYLIGHT
TZNAME:CEST
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
DTSTART:19810329T030000
RRULE:FREQ=YEARLY;INTERVAL=1;BYMONTH=3;BYDAY=-1SU
END:DAYLIGHT
BEGIN:STANDARD
TZNAME:CET
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
DTSTART:19961027T030000
RRULE:FREQ=YEARLY;INTERVAL=1;BYMONTH=10;BYDAY=-1SU
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
UID:DSC-20155
DTSTART;TZID=Europe/Berlin:20230922T110000
SEQUENCE:1695447333
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20230922T120000
URL:https://dresden-science-calendar.org/calendar/de/detail/20155
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Wong: Mitotic centrosomes are assembled upon inter-dependent solid-
  and liquid-like scaffolds
CLASS:PUBLIC
DESCRIPTION:Speaker: Isaac Siu-Shing Wong\nInstitute of Speaker: Sir Willia
 m Dunn School of Pathology\, University of Oxford\nTopics:\n\n Location:\n
   Name: MPI-CBG (MPI-CBG Galleria)\n  Street: Pfotenhauerstraße 108\n  Ci
 ty: 01307 Dresden\n  Phone: +49 351 210-0\n  Fax: +49 351 210-2000\nDescri
 ption: Mitotic centrosomes are formed when centrioles recruit pericentriol
 ar material (PCM) around themselves. The PCM comprises several hundred pro
 teins\, and its physical nature is hotly debated. In flies\, Spd-2/CEP192 
 recruits Polo/PLK-1 and Cnn/CDK5RAP2 (fly/human nomenclature) to the centr
 iole\, and these form a solid-like scaffold that recruits PCM clients. Her
 e we show that Spd-2 also recruits a liquid-like scaffold to centrioles th
 at depends on Aurora A and TACC and is analogous to the liquid-like spindl
 e domain (LISD) in mammalian acentrosomal meiotic spindles. The Polo/Cnn a
 nd Aurora A/TACC scaffolds can assemble and recruit PCM clients independen
 tly of one another\, but centrosome function is severely perturbed in the 
 absence of either scaffold. Thus\, mitotic centrosomes in flies assemble u
 pon co-existing solid- and liquid-like scaffolds organised by Spd-2/CEP192
  and either Polo/PLK1 or Aurora A\, respectively.
DTSTAMP:20260413T004314Z
CREATED:20230916T053934Z
LAST-MODIFIED:20230923T053533Z
END:VEVENT
END:VCALENDAR