BEGIN:VCALENDAR
VERSION:2.0
PRODID:www.dresden-science-calendar.de
METHOD:PUBLISH
CALSCALE:GREGORIAN
X-MICROSOFT-CALSCALE:GREGORIAN
X-WR-TIMEZONE:Europe/Berlin
BEGIN:VTIMEZONE
TZID:Europe/Berlin
X-LIC-LOCATION:Europe/Berlin
BEGIN:DAYLIGHT
TZNAME:CEST
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
DTSTART:19810329T030000
RRULE:FREQ=YEARLY;INTERVAL=1;BYMONTH=3;BYDAY=-1SU
END:DAYLIGHT
BEGIN:STANDARD
TZNAME:CET
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
DTSTART:19961027T030000
RRULE:FREQ=YEARLY;INTERVAL=1;BYMONTH=10;BYDAY=-1SU
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
UID:DSC-20509
DTSTART;TZID=Europe/Berlin:20240418T130000
SEQUENCE:1713418800
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20240418T140000
URL:https://dresden-science-calendar.org/calendar/de/detail/20509
LOCATION:TUD CRTD\, Fetscherstraße 10501307 Dresden
SUMMARY:Gouti: CMCB Life Sciences Seminar: Dr. Mina Gouti\, Max-Delbruck Ce
 nter for Molecular Medicine\, Berlin
CLASS:PUBLIC
DESCRIPTION:Speaker: Dr. Mina Gouti\nInstitute of Speaker: Max-Delbruck Cen
 ter for Molecular Medicine (MDC)\, Berlin\nTopics:\nWillkommen\n Location:
 \n  Name: TUD CRTD ()\n  Street: Fetscherstraße 105\n  City: 01307 Dresde
 n\n  Phone: +49 (0)351 458 82052\n  Fax: +49 (0)351 458 82059 \nDescriptio
 n: <p><strong>Host: </strong>Konstantinos Anastassiadis (BIOTEC)</p>  <p><
 strong>Title: </strong>“Building advanced neuromuscular organoids to stu
 dy human development and disease“</p>  <p>Mina Gouti is a group leader a
 t the Max Delbrück Center for Molecular Medicine in Berlin. She works at 
 the interface of developmental biology\, stem cell research and organoid t
 echnologies. Her lab has pioneered the generation of 3D human neuromuscula
 r organoids (NMOs) from human pluripotent stem cell-derived neuromesoderma
 l progenitor cells (Martins et al\, Cell Stem Cell\, 2020). The generation
  of human neuromuscular organoids opened up new opportunities for studying
  and treating neurodegenerative and neuromuscular diseases. Mina Gouti is 
 an EMBO young investigator and has received several distinctions and award
 s\, including an ERC Consolidator Grant and an ERC Proof of Concept grant.
 </p>  <p><strong>Abstract: </strong>Locomotion results from the interactio
 n between muscles and the nervous system. Dysfunction of such cells result
 s in deadly diseases such as spinal muscular atrophy (SMA) and amyotrophic
  lateral sclerosis (ALS). Neuromuscular diseases often show regional selec
 tivity but the underlying reasons remain obscure due to the lack of a suit
 able human model system. We have recently used human pluripotent stem cell
  derived axial stem cells\, the building blocks of the posterior body\, to
  simultaneously generate spinal cord neurons and skeletal muscle cells tha
 t self-organize in 3D to generate neuromuscular organoids (NMOs). NMOs con
 tain functional neuromuscular junctions supported by terminal Schwann cell
 s. They contract and develop central pattern generator-like neuronal circu
 its. We are currently applying NMOs to study the early development of the 
 human neuromuscular system and to model neuromuscular diseases. This appro
 ach promises to uncover the sequence of events and provide greater insight
  into the mechanisms that lead to specific diseases by tackling previously
  inaccessible features of neuromuscular junction biology.</p>
DTSTAMP:20260411T083341Z
CREATED:20240208T064037Z
LAST-MODIFIED:20240418T054000Z
END:VEVENT
END:VCALENDAR