BEGIN:VCALENDAR
VERSION:2.0
PRODID:www.dresden-science-calendar.de
METHOD:PUBLISH
CALSCALE:GREGORIAN
X-MICROSOFT-CALSCALE:GREGORIAN
X-WR-TIMEZONE:Europe/Berlin
BEGIN:VTIMEZONE
TZID:Europe/Berlin
X-LIC-LOCATION:Europe/Berlin
BEGIN:DAYLIGHT
TZNAME:CEST
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
DTSTART:19810329T030000
RRULE:FREQ=YEARLY;INTERVAL=1;BYMONTH=3;BYDAY=-1SU
END:DAYLIGHT
BEGIN:STANDARD
TZNAME:CET
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
DTSTART:19961027T030000
RRULE:FREQ=YEARLY;INTERVAL=1;BYMONTH=10;BYDAY=-1SU
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
UID:DSC-20566
DTSTART;TZID=Europe/Berlin:20240318T110000
SEQUENCE:1710830329
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20240318T120000
URL:https://dresden-science-calendar.org/calendar/de/detail/20566
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Bolondi: From embryos to stem cells: charting quantitative landscap
 es of mammalian development
CLASS:PUBLIC
DESCRIPTION:Speaker: Adriano Bolondi\nInstitute of Speaker: Dept. of Genome
  Regulation\, MPI for Molecular Genetics\, Berlin\nTopics:\n\n Location:\n
   Name: MPI-CBG (MPI-CBG Auditorium)\n  Street: Pfotenhauerstraße 108\n  
 City: 01307 Dresden\n  Phone: +49 351 210-0\n  Fax: +49 351 210-2000\nDesc
 ription: Mammalian development is a highly orchestrated process where mill
 ions of cells move in concert to ensure the formation of diverse tissues a
 nd organs. In particular\, during gastrulation and early organogenesis\, a
  relatively homogenous group of pluripotent cells rapidly diversify to sha
 pe complex morphological domains with specialized functions. These intrica
 te processes require multiple regulative layers that dynamically crosstalk
  to guarantee developmental robustness\, including the interactions betwee
 n genes\, cells\, and the extracellular environment. Despite foundational 
 work in the past century\, quantitative measurements of these dynamic inte
 ractions remain challenging\, mainly because of the embryo inaccessibility
  in the maternal womb and the lack of adequate tools to decode its complex
 ity. I will present novel stem cell-based and genomic approaches that we d
 eveloped to make mammalian embryogenesis more accessible and tunable\, inc
 luding enhanced in vitro models\, 3D spatial transcriptomic maps\, and sin
 gle-cell genetic lineage tracing technologies. This innovative toolkit all
 owed us to assess the role of the extracellular matrix in tissue morphogen
 esis\, study the spatial organization of gene expression in mutant embryos
 \, and chart complex developmental trajectories during critical windows of
  mammalian development.
DTSTAMP:20260701T194438Z
CREATED:20240302T063828Z
LAST-MODIFIED:20240319T063849Z
END:VEVENT
END:VCALENDAR