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UID:DSC-22891
DTSTART;TZID=Europe/Berlin:20260518T140000
SEQUENCE:1779082568
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20260518T150000
URL:https://dresden-science-calendar.org/calendar/de/detail/22891
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Chen: Developmental regulation of Erk signaling by mitotic kinases
CLASS:PUBLIC
DESCRIPTION:Speaker: Fei Chen\nInstitute of Speaker: MPI for Molecular Biom
 edicine\, Münster\nTopics:\n\n Location:\n  Name: MPI-CBG (MPI-CBG CBG Ga
 lleria II (VC))\n  Street: Pfotenhauerstraße 108\n  City: 01307 Dresden\n
   Phone: +49 351 210-0\n  Fax: +49 351 210-2000\nDescription: During the p
 eri-­implantation phase of murine embryogenesis\, the epiblast proliferat
 es rapidly and undergoes epithelialization. At the same time\, the preimpl
 antation pluripotent state transforms into a more developmentally advanced
 \, pregastrulation state. While extensive research has elucidated cell-­ 
 extrinsic signals that direct the developmental progression\, such as the 
 Fgf/Mek/Erk pathway\, the potential interplay of intrinsic cellular cues r
 emains largely unexplored. To address this\, we conducted a comprehensive 
 phenotypic screen using an in vitro model of epiblast development. We iden
 tified aurora kinase A as a cell-­ intrinsic factor contributing to Erk a
 ctivation and transcriptional response. Consequently\, suppressing aurora 
 kinase A activity delayed exit from naïve pluripotency. Moreover\, our re
 sults show that upon entry into mitosis\, Erk relocates to the cell divisi
 on machinery. We found that in dividing cells\, a fraction of Erk\, with y
 et elusive functions\, localizes on the centrosomes\, where its phosphoryl
 ation depends on polo-­like kinase 1.
DTSTAMP:20260613T142408Z
CREATED:20260512T053711Z
LAST-MODIFIED:20260518T053608Z
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