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UID:DSC-20100
DTSTART;TZID=Europe/Berlin:20230921T150000
SEQUENCE:1695361058
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20230921T160000
URL:https://dresden-science-calendar.org/calendar/en/detail/20100
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Ventura: How do cells fit in? Understanding the mechanisms underlyi
 ng epithelial morphogenesis
CLASS:PUBLIC
DESCRIPTION:Speaker: Guilherme Bastos Ventura\nInstitute of Speaker: Univer
 sity of Copenhagen Novo Nordisk Foundation Center for Stem Cell Medicine (
 reNEW)\nTopics:\n\n Location:\n  Name: MPI-CBG (MPI-CBG Galleria)\n  Stree
 t: Pfotenhauerstraße 108\n  City: 01307 Dresden\n  Phone: +49 351 210-0\n
   Fax: +49 351 210-2000\nDescription: During embryonic development\, tissu
 es evolve into intricate collectives that combine different specialized ce
 ll types. To create such complex ensembles\, specialized precursor cells o
 ften move to integrate the target tissues where they execute their functio
 n. While much is known about the biochemical signals controlling cell move
 ment in vivo\, comparatively little is known about how mechanical stimuli 
 from the environment direct migrating precursors. To address this question
 \, we focus on the specialized precursor cells integrating the epidermis o
 f the Xenopus embryo\, using quantitative live imaging and mathematical mo
 deling to characterize this process. Here\, we describe how\, during integ
 ration\, the multiciliated cell (MCC) precursors extend actin-based filopo
 dia directed at the epithelial vertices of neighboring epidermal cells. As
  the integrating precursors interact with their neighbors\, they pull on t
 he epithelial vertices through a mechanism that depends on the force gener
 ating motor myosin-II and the activity of a novel regulator of cell integr
 ation\, LSR. To interpret our in vivo findings\, we have designed a theore
 tical framework that models the physical environment of the epidermis duri
 ng precursor integration. Our model and experimental data show that MCC pr
 ecursors pull at the epithelial vertices to probe the local mechanical pro
 perties and identify suitable positions for cell integration. This pulling
  mechanism also equips MCC precursors with the ability to actively remodel
  their neighbors\, and effectively generate a permissive environment that 
 facilitates integration. Altogether\, our work defines a novel durotaxis-l
 ike mechanism driving the integration of specialized precursors within a d
 eveloping tissue\, and highlights how individual migrating precursors can 
 act as drivers of morphogenesis.
DTSTAMP:20260411T062847Z
CREATED:20230826T053932Z
LAST-MODIFIED:20230922T053738Z
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