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UID:DSC-20116
DTSTART;TZID=Europe/Berlin:20230921T130000
SEQUENCE:1695274558
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20230921T140000
URL:https://dresden-science-calendar.org/calendar/en/detail/20116
LOCATION:TUD CRTD\, Fetscherstraße 10501307 Dresden
SUMMARY:CMCB Life Science Seminar: Prof. Sonja Schmid\, Wageningen Universi
 ty &amp\; Research\, Labortatory of Biophysics\, The Netherlands
CLASS:PUBLIC
DESCRIPTION:Speaker: \nInstitute of Speaker: \nTopics:\nWillkommen\n Locati
 on:\n  Name: TUD CRTD ()\n  Street: Fetscherstraße 105\n  City: 01307 Dre
 sden\n  Phone: +49 (0)351 458 82052\n  Fax: +49 (0)351 458 82059 \nDescrip
 tion: <p><strong>Host: </strong>Michael Schlierf (B CUBE)</p>  <p><strong>
 Title: </strong>“Dissecting the molecular driving forces of life with si
 ngle-molecule resolution”</p>  <p><strong>Abstract: </strong>Proteins ar
 e the molecular makers in our body. Researchers successfully identified a 
 vast proteome\, a dense web of metabolic interactions\, and many thousands
  of static 3D structures. But the essential dynamic processes causing prot
 ein function are still challenging to detect – yet they are the key to t
 he energetics controlling life at the nanoscale. We therefore focus on acq
 uiring time-resolved information to reveal the nano-dynamics of biomolecul
 ar systems\, such as cancer-assisting chaperone\, kinase proteins\, and CR
 ISPR-associated proteins.</p>  <p>In this talk\, I will present our latest
  results from optical and electrical single-molecule experiments. FRET all
 ows us to watch single proteins at work in real time [1\,2\,3]\, and with 
 our DyeCycling approach [4]\, we can now overcome its infamous photobleach
 ing limitation and detect previously hidden kinetic phenomena. In addition
 \, we recently presented the NEOtrap 2.0\, a label-free technique to monit
 or the time evolution of single unmodified proteins electrically\, using n
 anopores [5\,6]. Lastly\, I will share how we revealed the hidden power of
  type-III CRISPR-Cas – one-by-one. Our overarching mission is to push be
 yond current detection limits\, to learn how biomolecular function arises 
 at the nanoscale.</p>
DTSTAMP:20260408T132356Z
CREATED:20230907T053958Z
LAST-MODIFIED:20230921T053558Z
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