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UID:DSC-20444
DTSTART;TZID=Europe/Berlin:20240122T110000
SEQUENCE:1705991923
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20240122T120000
URL:https://dresden-science-calendar.org/calendar/en/detail/20444
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Seal: Characterizing the gene-regulatory-network controlling neural
  crest development: from induction to migration
CLASS:PUBLIC
DESCRIPTION:Speaker: Subham Seal\nInstitute of Speaker: Institut Curie – 
 Research Centre\, Orsay\, France.\nTopics:\n\n Location:\n  Name: MPI-CBG 
 (CSBD SR Top Floor)\n  Street: Pfotenhauerstraße 108\n  City: 01307 Dresd
 en\n  Phone: +49 351 210-0\n  Fax: +49 351 210-2000\nDescription: The neur
 al crest is a multipotent population in the vertebrate embryo\, which aris
 es from the neural border\, undergoes EMT at the end of neurulation\, and 
 migrates to different parts of the embryo. At their final destinations\, t
 he neural crest cells differentiate into a host of different derivatives\,
  such as neurons\, glia\, melanocytes and connective tissue\, making the n
 eural crest an important contributor of embryogenesis. Although many genes
  controlling these different processes have been individually studied\, th
 e complete gene-regulatory-network remains to be elucidated. In our lab\, 
 through the intersection of different high-throughput techniques like scRN
 Aseq and ChIPseq\, not only have we identified potential regulators\, but 
 also validated some of their functions on a large scale. In the poorly-stu
 died premigratory neural crest population\, we have observed early fate pr
 edispositions in the neural crest population\, as well as a retention of m
 ultipotency characteristics till late neurula stages. Further\, at earlier
  (gastrula) stages\, we have also identified novel candidates driving the 
 fate specification of the neural border into the neural crest and the cran
 ial placodes. On the other hand\, we also use candidate-based approaches t
 o study the mechanisms of function of the identified genes in greater deta
 il\, such as Prdm12\, a transcription factor with H3K4 methyl transferase 
 activity. During early neurula stages\, Prdm12 restricts the expression of
  neural crest genes to establish the boundaries of the different ectoderma
 l domains. However\, at a later stage\, we observe that Prdm12 affects neu
 ral crest migration at a later stage through modulating the expression of 
 cadherins and the Wnt pathway. Through my talk\, I will present an overvie
 w of how we use these multiple different approaches to study the different
  genes at the scale of a regulatory network.
DTSTAMP:20260420T204412Z
CREATED:20240116T063824Z
LAST-MODIFIED:20240123T063843Z
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