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UID:DSC-20718
DTSTART;TZID=Europe/Berlin:20240502T130000
SEQUENCE:1714628255
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URL:https://dresden-science-calendar.org/calendar/en/detail/20718
LOCATION:B CUBE\, Tatzberg 4101307 Dresden
SUMMARY:CMCB Life Sciences Seminar: Dr. Oliver Thorn-Seshold\, LMU München
CLASS:PUBLIC
DESCRIPTION:Speaker: \nInstitute of Speaker: \nTopics:\nWillkommen\n Locati
 on:\n  Name: B CUBE ()\n  Street: Tatzberg 41\n  City: 01307 Dresden\n  Ph
 one: +49 351 463 43000\n  Fax: +49 351 463 40322\nDescription: <p><strong>
 Host: </strong>Stefan Diez (B CUBE)</p>  <p><strong>Title: \"</strong>From
  Photocontrolling Cytoskeleton &amp\; Channel Function\, to Photostabilisi
 ng Fluorophores for High-Performance Imaging: What Chemistry can do for Yo
 u\"<strong> </strong></p>  <p><strong>Abstract: </strong></p>  <p>Small mo
 lecule drugs and fluorophores are irreplaceable everyday reagents in biolo
 gy\, to modulate and to image biological processes in action. Both these c
 lasses of reagents are continuously being engineered and functionalised fo
 r cutting-edge applications. This talk presents ongoing work in our group\
 , in two areas of <strong>photoresponsive reagent engineering</strong>:</p
 >  <p><strong>1. Photocontrol in Biology:</strong> we are developing photo
 responsive tool compounds to control biological processes with second-and
 -micron scale precision. Particularly\, we focus on:</p>  <ul>  <li><stron
 g>Microtubule dynamics and architecture</strong>\, where our photo-tools c
 an non-invasively modulate cell division\, migration\, and tissue developm
 ent\, in cells and in vivo<strong>\;                   
       </strong></li>  <li><strong>Ion channels\, receptors\, and memb
 ranes</strong>\, where the unparalleled temporal resolution and biological
  efficacy that photoswitchable tools can harness is opening up avenues for
  biophysics\, signaling\, and neuroscience.</li> </ul>  <p><strong>2. High
 -Performance Imaging:</strong> we are improving chromophore scaffolds\, ai
 ming to deliver:</p>  <ul>  <li><strong>Ultra-photostable fluorophores</st
 rong>: for super-resolution and long-term imaging with low phototoxicity a
 nd intrinsic quantitative response</li>  <li><strong>Red/NIR-light protein
  photocontrol in vivo</strong>\, by re-imagining classical photoresponsive
  drug design: e.g. for neuroscience studies\, with noninvasive transcrania
 l NIR illumination to control animal behaviour.</li> </ul>  <p><strong>Eve
 rybody is very welcome!</strong></p>
DTSTAMP:20260708T141501Z
CREATED:20240321T063806Z
LAST-MODIFIED:20240502T053735Z
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