BEGIN:VCALENDAR
VERSION:2.0
PRODID:www.dresden-science-calendar.de
METHOD:PUBLISH
CALSCALE:GREGORIAN
X-MICROSOFT-CALSCALE:GREGORIAN
X-WR-TIMEZONE:Europe/Berlin
BEGIN:VTIMEZONE
TZID:Europe/Berlin
X-LIC-LOCATION:Europe/Berlin
BEGIN:DAYLIGHT
TZNAME:CEST
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
DTSTART:19810329T030000
RRULE:FREQ=YEARLY;INTERVAL=1;BYMONTH=3;BYDAY=-1SU
END:DAYLIGHT
BEGIN:STANDARD
TZNAME:CET
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
DTSTART:19961027T030000
RRULE:FREQ=YEARLY;INTERVAL=1;BYMONTH=10;BYDAY=-1SU
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
UID:DSC-20736
DTSTART;TZID=Europe/Berlin:20240412T110000
SEQUENCE:1712986806
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20240412T120000
URL:https://dresden-science-calendar.org/calendar/en/detail/20736
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Sumbal: Contractile fibroblasts are recruited to growing mammary ep
 ithelium to support branching morphogenesis
CLASS:PUBLIC
DESCRIPTION:Speaker: Jakub Sumbal\nInstitute of Speaker: Sorbonne Universit
 é\, Paris\, France &amp\; Faculty of Medicine\, Masaryk University\, Brno
 \, Czech Republic\nTopics:\n\n Location:\n  Name: MPI-CBG (MPI-CBG Auditor
 ium)\n  Street: Pfotenhauerstraße 108\n  City: 01307 Dresden\n  Phone: +4
 9 351 210-0\n  Fax: +49 351 210-2000\nDescription: Fibroblasts are stromal
  cells of connective tissue\, which are critical for organ development\, h
 omeostasis and disease. Single cell transcriptomic analyses have revealed 
 a great level of inter- and intra-organ heterogeneity of fibroblasts\, how
 ever\, the functional implications and lineage relations of different fibr
 oblast subtypes are unknown. In the mammary gland\, fibroblasts support al
 l stages of development\, including branching morphogenesis\, as well as t
 he transition into breast cancer. Here we characterized pubertal mammary f
 ibroblasts using single cell RNA sequencing\, spatial mapping and in vivo 
 lineage tracing and discovered a transient niche-forming population of con
 tractile fibroblasts that specifically localize around growing epithelium 
 after being recruited from the surrounding fat pad. Using functional organ
 oid experiments we revealed that fibroblast contractility is needed for ep
 ithelial morphogenesis and that different fibroblast populations are activ
 ated by contact with the epithelium to support its morphogenesis. In summa
 ry\, our detailed characterization brings new insight into mammary fibrobl
 ast heterogeneity\, including functional relevance for epithelial morphoge
 nesis and lineage hierarchy during normal mammary gland development in mic
 e.
DTSTAMP:20260501T164632Z
CREATED:20240328T063650Z
LAST-MODIFIED:20240413T054006Z
END:VEVENT
END:VCALENDAR