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UID:DSC-21383
DTSTART;TZID=Europe/Berlin:20241022T110000
SEQUENCE:1729575568
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20241022T120000
URL:https://dresden-science-calendar.org/calendar/en/detail/21383
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Pönisch: \"Cell shape noise and morphogenetic attractors control c
 ell shape change during epithelial-to-mesenchymal transition\"
CLASS:PUBLIC
DESCRIPTION:Speaker: Iskra Yanakieva and Wolfram Pönisch\nInstitute of Spe
 aker: University of Cambridge\nTopics:\n\n Location:\n  Name: MPI-CBG (MPI
 -CBG: Galleria)\n  Street: Pfotenhauerstraße 108\n  City: 01307 Dresden\n
   Phone: +49 351 210-0\n  Fax: +49 351 210-2000\nDescription: Cell shape c
 hanges play a fundamental role in development and disease\, often accompan
 ying transitions in cell state. Despite the importance of cellular shape f
 or biological function\, most studies investigating state transitions focu
 s on gene expression changes. Here\, we combine morphometric analysis with
  stochastic inference\, mathematical modelling\, and molecular perturbatio
 ns to interrogate cell shape dynamics during epithelial-to-mesenchymal tra
 nsition (EMT). We extract a low-dimensional representation of the morphoge
 netic landscape associated with EMT and show that EMT-associated cell spre
 ading corresponds to a transition between cell shape attractors within thi
 s landscape. Strikingly\, we observe a peak in cell shape noise at the tim
 e of spreading. Theoretical modelling and experimental perturbations show 
 that shape noise plays a functional role in cell spreading\, accelerating 
 the transition between shape attractors. Together\, our study characterize
 s the morphogenetic landscape of EMT-associated cell spreading\, a framewo
 rk that will be widely applicable to investigate shape changes in physiolo
 gy and disease. Overall\, our findings reveal that cellular noise is not m
 erely a signature of cell shape changes but influences how they occur\, of
 fering new insights into the functional role of noise.
DTSTAMP:20260418T000320Z
CREATED:20241017T053905Z
LAST-MODIFIED:20241022T053928Z
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