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UID:DSC-22853
DTSTART;TZID=Europe/Berlin:20260520T140000
SEQUENCE:1779255436
TRANSP:OPAQUE
DTEND;TZID=Europe/Berlin:20260520T150000
URL:https://dresden-science-calendar.org/calendar/en/detail/22853
LOCATION:MPI-CBG\, Pfotenhauerstraße 10801307 Dresden
SUMMARY:Lerchbaumer: Using targeted manipulation of cell adhesion to study 
 tissue properties during morphogenesis
CLASS:PUBLIC
DESCRIPTION:Speaker: Gerald Lerchbaumer\nInstitute of Speaker: University o
 f Toronto\, Canada\nTopics:\n\n Location:\n  Name: MPI-CBG (MPI-CBG CBG SR
  4)\n  Street: Pfotenhauerstraße 108\n  City: 01307 Dresden\n  Phone: +49
  351 210-0\n  Fax: +49 351 210-2000\nDescription: Cell adhesion is essenti
 al for shaping tissues during animal development\, yet how adhesion is tun
 ed to support different morphogenetic movements remains unclear. We used o
 ptogenetics in the Drosophila embryo to address this question by enhancing
  clustering of E-cadherin\, a core component of adherens junctions. Increa
 sing E-cadherin clustering enriches E-cadherin at junctions and reduces it
 s mobility\, consistent with enhanced adhesion strength. This approach all
 ows targeted manipulation of cellular adhesive properties in vivo and make
 s it possible to address questions that were previously difficult to test 
 directly. By analyzing animal development while increasing cell adhesion t
 hroughout the epithelial tissue\, we found that this causes a strong reduc
 tion in cell rearrangements during epithelial morphogenesis and disrupts c
 onvergent extension of the embryonic axis. To further understand these eff
 ects\, we adapted a vertex model to include adhesion-dependent friction be
 tween cells. The model predicts that stronger adhesion increases resistanc
 e to neighbor exchange and thereby limits tissue remodeling. To test this 
 idea\, we analyzed different morphogenetic movements in the fly and their 
 dependence on cell adhesion. We found that enhanced E-cadherin clustering 
 strongly slows morphogenetic processes that depend on both cell shape chan
 ge and cell rearrangement\, while movements that rely primarily on apical 
 constriction can still proceed. Together\, these findings suggest that E-c
 adherin clustering is an important regulator of tissue mechanics and that 
 tuning adhesion is critical for morphogenetic events that require dynamic 
 cell-cell rearrangements
DTSTAMP:20260610T234606Z
CREATED:20260422T053550Z
LAST-MODIFIED:20260520T053716Z
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