Analyzing surgical smoke by differential mobility spectrometry: From theory to clinical applications

Date

Nov 5, 2026

Time

1:00 PM - 3:00 PM

Speaker

Phillipp Müller

Affiliation

Faculty of Medicine and Health Technology Tampere, Finland

Series

TUD nanoSeminar

Language

en

Main Topic

Physik

Other Topics

Physik

Host

Arezoo Dianat

Description

Most solid cancer tumors, such as breast cancer and brain tumors, are frequently treated by surgeries, in which only cancerous tissue should be removed. However, identifying the margin (i.e. border between tumor and healthy tissue) visually is at best challenging. For the surgical removal of tissue diathermy knifes or electric bipolar forceps are frequently used to decrease bleeding. The procedure produces surgical smoke that contains cell metabolites. An emerging and promising technique for molecular analysis of surgical smoke is differential mobility spectrometry (DMS), which employs an electric field consisting of an asymmetric oscillating high intensity field and a low static field component to obtain information on the electric field-mobility dependence of ions. One bottleneck for the widespread application of DMS for the analysis during tumor resection is the dependence of DMS measurements on environmental parameters such as humidity, temperature and pressure. This talk will present an overview on our recent work on distinguishing cancerous and non-cancerous tissue based on surgical smoke measured by DMS, with a focus on compensating the impact of environmental parameters on the DMS measurements.

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Last modified: Aug 27, 2026, 7:37:47 AM